The U.S. Department of Energy (DOE) has established collaboration agreements with 24 organizations—including Accenture, AMD, Amazon Web Services, Google, IBM, Intel, Microsoft, and NVIDIA—to advance the Genesis Mission, a national effort leveraging artificial intelligence (AI) to accelerate discovery science and strengthen national security. This initiative builds upon President Trump’s Executive Order and America’s AI Action Plan, aiming to establish a scalable national infrastructure for scientific advancement. The Genesis Mission will focus on automating experiment design, accelerating simulations, and generating predictive models to drive breakthroughs across energy, manufacturing, and drug discovery. Interestingly there are no pure-play quantum computing or quantum technology companies listed.
- Accenture
- AMD
- Anthropic
- Armada
- Amazon Web Services
- Cerebras
- CoreWeave
- Dell
- DrivenData
- Groq
- Hewlett Packard Enterprise
- IBM
- Intel
- Microsoft
- NVIDIA
- OpenAI
- Oracle
- Periodic Labs
- Palantir
- Project Prometheus
- Radical AI
- xAI
- XPRIZE
Genesis Mission Goals: Accelerating Science and Innovation
The U.S. Department of Energy has initiated the Genesis Mission, a national effort leveraging artificial intelligence (AI) to accelerate discovery science and drive energy innovation. Agreements have been established with 24 organizations – including companies like AMD, Google, and NVIDIA – to collaborate on this initiative. This mission directly supports President Trump’s Executive Order and America’s AI Action Plan, aiming to remove barriers to innovation and strengthen America’s scientific enterprise through AI technologies.
The Genesis Mission intends to dramatically increase the productivity of American scientists and researchers by automating experiment design and accelerating simulations. The focus extends beyond energy, with potential breakthroughs anticipated in areas like manufacturing and drug discovery. Agreements were signed with organizations responding to Requests for Information (RFIs), and any resulting products will be architecture-agnostic, ensuring broad applicability within the U.S. R&D ecosystem.
Two RFIs remain open to expand collaboration: “Partnerships for Transformational Artificial Intelligence Models” (closing Jan. 14, 2026) and “Transformational AI Capabilities for National Security” (closing Jan. 23, 2026). The Department of Energy welcomes further submissions and encourages interested parties to contact genesismission-partnerships@hq.doe.gov for partnership information or visit www.genesis.energy.gov for the latest mission details.
Collaboration Agreements with Partner Organizations
The U.S. Department of Energy (DOE) announced collaboration agreements with 24 organizations to advance the Genesis Mission, a national effort leveraging artificial intelligence (AI). These agreements build upon President Trump’s Executive Order and America’s AI Action Plan, aiming to remove barriers to innovation and reduce reliance on foreign entities. The partnerships involve companies, universities, non-profits, and Federal agencies, all uniting to accelerate discovery science, strengthen national security, and drive energy innovation through AI.
These collaborations formalized through memorandums of understanding (MOUs) stem from responses to DOE Requests for Information (RFIs) or existing projects with National Laboratories. Organizations involved include major technology companies like AMD, Amazon Web Services, Google, IBM, Microsoft, NVIDIA, and OpenAI, as well as research-focused entities like Cerebras and xAI. Any resulting products will be designed to be architecture-agnostic, ensuring broad applicability.
The DOE continues to seek additional collaborators through open RFIs, with the “Partnerships for Transformational Artificial Intelligence Models” RFI open until January 14, 2026, and the “Transformational AI Capabilities for National Security” RFI open until January 23, 2026. Interested parties can find more information at www.genesis.energy.gov or contact the mission directly at genesismission-partnerships@hq.doe.gov to explore partnership opportunities.
“Today’s announcement of 24 new research partnerships is only the beginning, as we deliver on President Trump’s mandate to bring the entire scientific community, including companies, universities, non-profits, and Federal agencies, into the Genesis Mission,”
Michael Kratsios
Ongoing and Future RFI Opportunities
The Department of Energy (DOE) is actively seeking collaborators for the Genesis Mission, a national effort leveraging artificial intelligence (AI) to accelerate scientific discovery. As of today, agreements have been signed with 24 organizations responding to Requests for Information (RFIs) or already engaged in related projects with DOE and National Laboratories. These partnerships aim to build a scalable national infrastructure and push the boundaries of science, with a focus on energy innovation, manufacturing, and drug discovery.
Currently, two RFIs remain open for submissions. The “Partnerships for Transformational Artificial Intelligence Models” RFI closes on January 14, 2026, while the “Transformational AI Capabilities for National Security” RFI is open until January 23, 2026. The DOE welcomes continued submissions to these open RFIs and anticipates future convenings to expand the number of qualified collaborators joining the Genesis Mission.
Interested organizations can find the latest information on the Genesis Mission at www.genesis.energy.gov and express partnership interest by emailing genesismission-partnerships@hq.doe.gov. These efforts support President Trump’s Executive Order and America’s AI Action Plan, aiming to remove barriers to innovation and reduce dependence on foreign adversaries through advancements in AI and scientific discovery.
