On November 24, 2025, the President launched the Genesis Mission, a national effort to accelerate artificial intelligence (AI) applications for transformative scientific discovery and address pressing national challenges. This initiative will establish an integrated AI platform leveraging decades of Federal investment in the world’s largest collection of scientific datasets to train foundation models and create AI agents. Led by the Assistant to the President for Science and Technology and implemented by the Secretary of Energy within the Department of Energy, the Genesis Mission aims to dramatically accelerate scientific breakthroughs, strengthen national security, and further America’s technological dominance.
Launching the Genesis Mission
The Genesis Mission was launched via Executive Order on November 24, 2025, establishing a national effort to accelerate scientific discovery using artificial intelligence. This initiative aims to address challenges comparable in urgency to the Manhattan Project, focusing on AI-enabled science to drive innovation and maintain American technological dominance. The mission will leverage Federal scientific datasets – the world’s largest collection – to train AI foundation models and create agents for hypothesis testing and research automation.
The Secretary of Energy is responsible for implementing the Genesis Mission within the Department of Energy, integrating all relevant resources into a secure, unified platform. Within 90 days of the order, the Secretary must identify available Federal computing, storage, and networking resources, including both on-premises and cloud-based high-performance systems. Within 120 days, a plan for incorporating datasets from various sources—federally funded research, agencies, and private partners—must be developed, prioritizing cybersecurity.
The American Science and Security Platform will serve as the infrastructure for the Genesis Mission, providing high-performance computing, AI modeling frameworks, and secure access to datasets. The Secretary must review capabilities across DOE national laboratories for robotic facilities capable of AI-directed experimentation within 240 days. An initial operating capability of the Platform, focused on at least one national challenge, is to be demonstrated within 270 days.
Establishment of the Genesis Mission
The Genesis Mission was formally established via Executive Order on November 24, 2025, as a national effort to accelerate scientific discovery using artificial intelligence. This initiative aims to address pressing national challenges by leveraging the world’s largest collection of Federal scientific datasets. The mission’s focus is on AI-enabled science, mirroring the ambition of projects like the Manhattan Project, and intends to strengthen national security, energy dominance, and workforce productivity through technological advancement.
The Secretary of Energy is responsible for implementing the Genesis Mission within the Department of Energy, integrating all relevant resources into a secure, unified platform. Within 90 days of the order, the Secretary must identify available Federal computing resources, including both on-premises and cloud-based high-performance computing systems. A plan for incorporating datasets from various sources—federally funded research, agencies, academia, and approved private partners—is due within 120 days, prioritizing cybersecurity measures.
A core component of the Genesis Mission is the American Science and Security Platform, designed to provide integrated access to high-performance computing, AI modeling frameworks, and domain-specific foundation models. Within 270 days of the order, the Secretary will review capabilities across DOE national laboratories for robotic facilities capable of AI-directed experimentation and manufacturing. The mission will initially focus on at least 20 science and technology challenges, spanning areas like advanced manufacturing and biotechnology.
From the founding of our Republic, scientific discovery and technological innovation have driven American progress and prosperity.
Operation of the American Science and Security Platform
The Genesis Mission establishes the American Science and Security Platform to function as its core infrastructure. This Platform will integrate several key resources, including high-performance computing – utilizing DOE national laboratory supercomputers and secure cloud environments – and AI modeling frameworks. Access to diverse datasets—proprietary, federally curated, and open—will be central, alongside AI-enabled predictive models and tools for autonomous experimentation and manufacturing, all while adhering to legal and security standards.
Within 90 days of the order, the Secretary of Energy must identify existing federal computing, storage, and networking resources—both on-premises and cloud-based—to support the Mission. Further investigation will also target potential partnerships and infrastructure enhancements. Within 120 days, initial data and model assets will be identified, focusing on digitization, standardization, and tracking their origin, alongside a plan for incorporating datasets from various sources with robust cybersecurity measures.
To demonstrate initial operating capability within 270 days, the Secretary will assess DOE national laboratories and facilities for robotic and production capabilities suitable for AI-directed experimentation. The Platform aims to address at least 20 national science and technology challenges – spanning areas like advanced manufacturing, biotechnology, and quantum information science – identified in coordination with the Assistant to the President for Science and Technology.
Identifying National Science and Technology Challenges
The Genesis Mission, established via Executive Order, directly addresses identifying national science and technology challenges. Within 60 days of the order (November 24, 2025), the Secretary of Energy is tasked with submitting a detailed list of at least 20 such challenges. These challenges should align with priority domains outlined in National Science and Technology Memorandum 2, dated September 23, 2025, to the Assistant to the President for Science and Technology (APST).
The APST will then review the Secretary’s list and, collaborating with agencies through the National Science and Technology Council (NSTC), create an expanded list. This expanded list will serve as the initial focus for the Genesis Mission’s efforts. Priority domains for these challenges include advanced manufacturing, biotechnology, critical materials, nuclear energy (fission and fusion), quantum information science, and semiconductors/microelectronics.
The ultimate goal of the Genesis Mission is to accelerate solutions to these identified challenges. This will be accomplished through the American Science and Security Platform, providing access to high-performance computing, AI modeling frameworks, and secure datasets. Within 270 days of the order, the Secretary aims to demonstrate initial operating capability of the Platform for at least one of these national science and technology challenges.
This order launches the “Genesis Mission” as a dedicated, coordinated national effort to unleash a new age of AI‑accelerated innovation and discovery that can solve the most challenging problems of this century.
Secretarial Responsibilities for Implementation
The Secretary of Energy is assigned primary responsibility for implementing the Genesis Mission within the Department of Energy (DOE). This includes setting priorities and integrating all DOE resources used for the Mission into a secure, unified platform. The Secretary may also designate a senior political appointee to oversee daily operations. Within 90 days of the order, the Secretary must identify available federal computing, storage, and networking resources, including both on-premises and cloud-based systems, to support the Mission’s infrastructure.
Within 120 days of the order, the Secretary will identify initial data and model assets for use in the Mission, focusing on digitization, standardization, and tracking data origins. A plan will be developed, with cybersecurity measures, for incorporating datasets from federally funded research, agencies, universities, and private partners, as appropriate. This work establishes the foundation for the American Science and Security Platform, which will provide access to high-performance computing and AI modeling tools.
The Secretary is also tasked with reviewing capabilities across DOE national laboratories and other facilities for robotic laboratories and production facilities capable of AI-directed experimentation and manufacturing within 240 days of the order. This review focuses on automated workflows and related technical standards. Within 270 days, the Secretary aims to demonstrate an initial operating capability of the Platform, addressing at least one national science and technology challenge.
Platform Infrastructure and Resource Development
The Genesis Mission establishes the American Science and Security Platform as its core infrastructure. This Platform will integrate high-performance computing resources, including DOE national laboratory supercomputers and secure cloud environments, to support large-scale AI model training. It will also incorporate AI modeling frameworks, computational tools like predictive models, and domain-specific foundation models. Secure access to diverse datasets – federally curated, proprietary, and open – is central to the Platform’s design, adhering to all relevant legal and security standards.
Within 90 days of the order, the Secretary of Energy is tasked with identifying available Federal computing, storage, and networking resources for the Mission, encompassing both on-premises and cloud-based systems, as well as potential industry partnerships. Following that, within 120 days, a plan will be developed to incorporate datasets from federally funded research, agencies, and approved private partners, prioritizing risk-based cybersecurity measures.
The Platform’s capabilities will also extend to experimental and production tools, enabling AI-directed experimentation and manufacturing in key domains. A review of robotic laboratories and production facilities across DOE national laboratories is mandated within 240 days, focused on automated workflows and necessary technical standards. An initial operating capability for at least one national challenge is targeted within 270 days, demonstrating the Platform’s potential.
